Niacin liver damage myth reddit. However, side effects can be unpleasant and even dangerous.

Niacin liver damage myth reddit That said, niacin much, much cheaper than NMN, which is why I think a lot of people cross their fingers that it's a good alternative. I bought vital nutrients 500mg slow release tablets and took it today but I've been reading up on it an saw that this version of niacin can cause severe liver damage. Firstly, I’m not a doctor and I’m not recommending anything. you can find MANY MANY blogs and website and treatment centers that assert that kava is toxic, however these are ALL based on the same misunderstanding of the 1998-2003 time period. Why are you on T? This is the warning about steroids and T. I will update every week. I just found this thread after googling: niacin heart reddit I'll explain what happened to me today, literally 2 hours ago: You are correct. Are you taking about raising liver enzymes as But is the liver harshness from 1g of Niacinamide really something to be careful about? Can it actually cause liver damage, or is it just an hypothesis? I think B-Complex is great, except for one thing. From what I read you need the flushing effect and not the slow release. The primary use of nicotinamide today is to treat nutritional There are many reports online of people fixing their sleep with this protocol. Excess niacin is metabolized by the liver using methyl groups. Now the question is, does niacin and 2PY actually damage artery wall cells? Sustained release niacin is bad for the liver. At higher doses: These doses could pose risks, such as liver damage, gastrointestinal problems, or glucose Niacin is a fuckall! 250 mg of Niacin gave me very low blood pressure and bad fatigue with in 48 hours of taking (just took it for 2 days and had to stop). Methods A total of 2946 participants from the National Health and Nutrition Examination Survey (NHANES) were carefully selected based on strict inclusion and exclusion For the past 6 months I have been taking 3g of niacin daily (regular, flush niacin) combined with a ketogenic diet. This is not a sign of liver damage, but a sign of raised liver activity. Niacin seems to be more tolerable over a longer term. The hepatocellular injury pattern is more common than the These doses could pose risks, such as liver damage, gastrointestinal problems, or glucose intolerance. There’s absolutely no worries with niacin/nicotinic acid. Taurine and Vitamin C are hepaprotective and safe to take daily along with I really doubt that time released niacin damages liver. Aim This study aims to explore the relationship between niacin intake and the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) within a large, multi-ethnic cohort. I have chest pain too. Will 250 mg of niacin at night do anything? Or should I go for higher doses? Thank you! Its the only vitamin apart from fat soluble that can cause liver damage Reddit . Top 18% Rank by size . I try not to take the Niacin near the time of any alcohol consumption since it is also metabolized by and can be hard on the liver. Take note that taking large doses of sustained-release niacin over a long period of time can cause liver damage. Niacin (vitamin B3) in high doses - which happens typically from supplementation, not food sources, can Sorry to be the bearer of bad news. It is niacin *non-flush* version that is extremely damaging to the liver. My liver numbers are normal now for the first time in so many years. According to this article, Tren is no harder on the liver than any other injectables, not as bad as any orals and so if someone is not already suffering from liver problems it shouldn't be an issue. The liver issues are most associated with flush free versions (niacinamide, not basic niacin). reReddit: Top posts of January 13, 2021. However, recently I came across a post on reddit where someone ranted about how niacin could lead to insulin resistance and liver damage. U Get app Get the Reddit app Log In Log in to Reddit. 26:43 Excess niacin will reduce the supply of methyl groups, which can lower creatine synthesis and affect neurotransmitters, and is probably what underlies niacin-induced liver damage. The “inositol hexanicotinate” form is. But long-term use is associated with liver damage. People confuse the two. From Mayo Clinic: High doses of niacin available via prescription can cause: "Severe skin flushing combined with dizziness, Rapid heartbeat, Itching, Nausea and vomiting, Abdominal pain, Diarrhea, Gout, Liver damage, Diabetes Serious side effects are most likely if you take between 2,000 to 6,000 mg of niacin a day. We have not seen any credible instances of toxicity in the last 20 years per the FDA. Niacin is not liver toxic. Up to 3000mg doses have been studied for people with schizophrenia being harmless so far. They might want to get a test. Posted by u/Special-Waltz5874 - 6 votes and 21 comments Depends on your mental health. I take 500 mg of Niacin every other night. Niacin and Impotence. 30:31 Explaining the stories of Julie, John, and Not overly, I take the supplement version not the one that you get prescribed (apparently they're different). 2g with Lion's Mane (350mg) makes the micro dose experience pleasantly hallucinogenic for me. More posts you may like r I am thinking of taking 500 mg of the non-flush kind of Niacin, 3 times a day. However, side effects can be unpleasant and even dangerous. And most of studies pointing at "Niacin is dangerous" facts are NOT nicotinic acid and if it does, the issue isn't directly a response of nicotinic acid but underlying issues or while on combination with other substances/drugs that are harsh on the liver. Most recently, researchers found a link between excess niacin and heart disease. St. Was this helpful? Niacin can cause mild-to-moderate serum aminotransferase elevations and high doses and certain formulations of niacin have been linked to clinically apparent, acute liver Liver damage. Here's a great summary from the The types of liver damage include hepatitis, cirrhosis, liver failure, and death (31,46–51). You only need 2mg per day, and higher amounts are neurotoxic. Makes my body hurt where my liver is and I feel like my throat is closing. Also. " Other than "heptatoxicity" what search terms can I put into Google scholar to research this? Re: use of niacin before nmn and NR came along Nausea may be an early warning sign of niacin-induced hepatotoxicity: if nausea occurs, the dose should be reduced, or treatment should be stopped. Heart damage, liver damage, and forget fatherhood, those testes are done. My liver was/is just really jacked up! I dropped some stuff and added some stuff. The side effects can be horrible. I always take it, and so does my dog. Considerations. You should not even think about low T until your 30's, unless born with a hormonal issue. The Nicotinic Acid form of niacin does not cause liver problems. Go back to the basics for why LDL might be high - thyroid panel, sex hormones panel, iron, b12, vitamin d, high copper/low zinc, etc. B-Complex contains 50mg+ of Vitamin B6. I have been taking high doses (3-4 G twice a day) of niacin for nine months now and blood work has been good. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; I’d have to be concerned about the liver in this situation since Aspirin is also metabolized by the liver, and Niacin is known to cause liver damage in some cases. At a time when so many people are taking large amounts of supplements, niacin toxicity is something of which to be aware. Taking niacin must have some effect on ketosis. No issues with liver except that guy that was taking nearly 5 grams like some over-achieving cunt. I take 500mg of nicotinic acid (niacin flush version) every night and my numbers are good. niagen is an essential element of my stack. Also that the kidney thing is kind of a myth which was started because of the fact that Tren discolors urine like vitamin B. I am so desperate to try this because of this Flush free niacin has far higher rate of liver issues and does nothing to improve cholesterol. Timed-release tablets deliver the vitamin more slowly, which reduces the intensity of the flushing. If niacin is consumed in high doses through supplements, it can lead to toxicity which can potentially cause digestive symptoms like nausea, vomiting, and even liver damage. But it is not harmful to your liver. I love using flushing If you take very high doses of niacin, you may incur liver damage after brief use. As for the liver issues, Niacin has been known to cause liver damage in extreme cases. I've been taking 3g a day for almost a decade now for Bipolar, it only took a few weeks to notice it was working well for me. Get the Reddit app Scan this Very Dangerous as it will damage your liver for sure Reply reply Ignorance_K1lls • If I could down vote this 100 times I would. Niacin, also known as vitamin B3, is required in regular amounts, usually acquired through diet. Expand user menu Open settings menu. Between 1940 and 1950, when the Caveat: high niacin dose, and my liver is weak when it comes to resisting damage. Get app Get the Reddit app Log In Log in to Reddit. Firstly, Niacin inhibits an enzyme called DGAT2 (diacylglycerol acyltransferase 2). That is a myth. This myth, which is pervasive in medicine, is based upon a series of observations, some of which were dead wrong. Regular niacin helps with cholesterol @ doses of 500 - 2000mg per day. This is a big win for the kava community, as well as for fact-based reporting. Pure niacin can also cause liver damage at 3000mg a day. Typically it's doses of 1500mg or more that are worrisome. Slow release no-flush niacin is actually inositol hexaniacinate and only breaks down to nicotinic acid after the first pass liver metabolism, liver burden should be avoided. Maybe it is not sticky stuff sticking to the vessel, but damage to the vessel being repaired with sticky stuff. It might help a bit for recovery. You can read about it in Abram Hoffer's book "Niacin". Liver damage is caused by niacinamide but NOT by niacin. Time-release has killed a few livers. It can cause insulin resistance, liver damage and so on. When it comes to the damage done by the alcohol. John's wort: This herbal supplement is used to treat depression, but it can also damage the liver. the NAC is not going to clean up the direct damage to your liver by needing to go through this process. The newest issue is the problem with Niacin breakdown products of 2PY and 4PY, but that data is horribly incomplete and needs substantial confirmation of causation rather than correlation as The smallest dose that is shown to cause liver problems in some people is 500 mg of slow release niacin, that is 10 times bigger than 50mg; most liver damage issues happen with higher dosages in the range of 1500-3000 mg though. It damages your liver. The issue is also that my ALT (Alanine Aminotransferease (SGPT)) and AST(Aspartate Aminotransferase (SGOT)) which indicate fatty liver and liver damage is also high - AST- 67 and ALT - 126. 5 is quite conservative, the average dose is around 2grams and they've done studies wayyyy above this Hello u/GozdaSeeker!Your comment has been automatically removed from r/microdosing because your account is less than 1 day old. I did read somewhere that high dose niacin is bad for the liver so it’s definitely worth at least getting a test for liver enzymes On the other hand, the other form of niacin (no flush) causes liver damage. Did yall know that it causes liver damage????? Update: My body is in rashes and I cant stop The only reason high dose Niacin is given is to reduce cholesterol. Some over-the-counter niacin tablets deliver the dose in a short burst, which makes the reaction more intense. Niacinamide seems to cause liver damage in some people. I never heard of it. If I take Niacin regularly & never miss a day, the flush is milder. if you take high doses of niacin, I suggest you also take TMG. As we get niacin from food all the time. I'm at the point now where i can't remember why I used to feel the way I did, until I run out and don't take it for a couple of weeks i notice I start feeling shitty. It is vitamin b3 but doesn’t do the same as the niacin. He has got experience with 50 years of high dose niacin therapy. I played with it many time but every time it causes problems I can do with out. ginseng and Niacin for post covid relief and I really don't think anything other than the Niacin is doing much. I was recently recommended to start a slow release niacin supplement by a nutritionist that I went to reguarding anxiety issues. Niacin often helps improve LDL but doesn't yield clear benefits for mortality - that should make you hesitant to take that approach. Also, the liver repairs itself. I know for example this holds true of sustain release niacin. I assume it is not beneficial to have steady high blood ketones for fat loss - burn them to unlock lipolysis. Don't switch from regular niacin to flush free niacin or rip liver, brah. If you have a dog, and you give them flea, tick, or heartworm treatments they should be on milk thistle to help combat the damage those chemicals do to their liver. Flushing, which is prostaglandin-mediated, is more common with immediate-release Niacin/nicotinic acid/flush niacin, immediate release niacin are various names for niaicin. OP is taking flush niacin. Both chronic and heavy use has been associated with cases of neurotoxicity, pulmonary hypertension, and dermatologic changes. There's no scientific literature indicating that niacin can cause liver damage. High doses of niacin cause: Flushing of the skin, Stomach upset (which usually subsides within a few weeks), Headache, Dizziness, Blurred vision, An increased risk of liver damage. So while the notion that genuine kava beverage causes liver problems is a myth, it is nevertheless a good idea to avoid "mysterious" pharmaceutical products or extracts, pills or pastes containing kava (often mixed with other substances) that do not come with any reliable information on the quality of the plant material used in their manufacturing. Flush niacin never creates liver damage, but can raise liver function tests to slightly above normal. You can listen to the 90 minute interview with Joe Mercola and Andrew Saul. 1. We are not talking about viruses here. I always have a flush unless I take some aspirin. In case anyone missed this, Dr. Niacin, in its forms of nicotinic acid and nicotinamide, is mainly metabolized in the liver. Learn More. Posted by u/Dechichete - 3 votes and 16 comments I took the Swanson brand a gram at a time. Niacin, also known as nicotinic acid and vitamin B3, is a water soluble, essential B vitamin that, when given in high doses, is effective in lowering low density lipoprotein (LDL) cholesterol and raising high density lipoprotein (HDL) cholesterol, which makes this agent of unique value in the therapy of dyslipidemia. Niacin , also known as vitamin B3, is made and used by your body to help convert foods that you eat into the energy you need. I had read that the non-flush kind was the one that causes liver damage. Always basics first. Or it exports them into bile, where they enter enterohepatic circulation, and finally they are excreted. Usually lasts about 45 minutes to an hour. Today I took Niacin for the first time (500mg) for my brain fog. Secondly, Niacin reduces the amount of oxidation in the cell Niacinamide is the only niacin who can cause liver damage. I have seen many family members that experienced sugar crashes and one one got insulin resistance in the liver. It can raise liver test levels, but there's no pathology behind it if the raise is not exorbitantly high. It's smart to take some simple liver protective agents like Vitamin C and Taurine along with the Niacin. 4, 8, 21, 22 This is the first demonstration of diffuse microvesicular steatosis, a feature seen in alcoholic foamy fatty liver disease, Reye’s syndrome, acute fatty liver disease of pregnancy, and The liver takes them up rapidly by scavenger receptors, and burns them to create ketones. Heavy kava consumption does effect the liver, but in relative terms is nowhere near what alcohol does. hope it helps! I want to take 1000mg extended release Niacinamide. I’ve been taking between 4 to 5 grams a day for about 10 years. Almost always with the extended release forms so don’t take those. There are so many resources out there for this, lots on YouTube and there are carnivore/zero carb forums on reddit and Facebook. . there is lots of proof you will get liver damage if you take a gram of niacin every day years ago they thought niacin was the magic cure for high cholesterol, they go through this nonsense every decade half a gram won't kill you apparently, if you feel it's helping go for it I just found this thread because I have been taking (not regularly Life Extension Niacin + TMG (500mg pills each) during few months but today I almost shit my pants. The dose of niacin (b3, not niacinamide or nicotinamide) where liver issues usually happen is around 1500mg daily, and is typically with the OTC ER formulas, not the IR formulas. Vision problems “Niacin should be avoided or used with caution in people with various conditions including liver disease, bleeding disorders, peptic ulcer disease, uncontrolled Niacin can also cause serious hepatoxicity that ranges from a mild elevation of liver enzymes to acute liver failure. Why locations like Sweden, Africa, Indian villages etc have drastically lower death rates than expected without intensive distancing measures (They supplement bread with nicotinic acid unlike many . In the meantime search “niacinamide nih liver damage” there’s so good and fairly readable studies on it. This filter is needed to deter spammers and scammers. No problem with the liver. Just documenting my personal experience. You can also help your body deal with it by backing it up with some TMG. With aspirin I’ll sleep through it. I would have expected people with these extreme niacin dosing regimens to run in to problems. Yes. It would be the equivalent of saying eating meals damages liver which isn’t true. I just start my MD journey yesterday but am waiting for my niacin to arrive. I've had issues with acetaminophen, statins, and oral AAS as well. HOWEVER. I can't find a solid answer anywhere that Niacin as nicotinic acid is known to potentially cause liver damage in doses above 800mg per day. But I'm super worried about any possible liver damage. I don’t have the time tonight, but I’ll try to look it up tomorrow. Reddit . your liver does not get the time to recover because it is processing alcohol still. Do NOT purchase sustained-release which is the longest acting version of 12 hours or more as that will almost certainly cause liver damage at high doses Eating something or taking an NSAID will generally reduce the flush That is a terrible wide spread myth and fake news, I was told NOT to use it when consuming alcohol as it can cause liver problems I don't drink anymore 6 years now. Log In / Sign Up; Advertise on Reddit; liver damage is a myth it is GOOD for your liver https: Does niacin hurt liver or not? There are many reports online of people fixing their sleep with this protocol. Niacinamide isn’t the same as niacin. It is not clear what doses were used and the period of use associated with the risk of liver damage. However, this type of niacin may cause liver damage in Niacin: Niacin is a vitamin that is essential for good health, but high doses of niacin can cause liver damage. For folks taking therapeutic doses of niacin, it's a good idea to have your doctor check your liver Quite possibly liver inflammation. Please wait at least 24 hours after you created your account to make a post or comment. Terrible itching sometimes. My liver function tests so far have been good (and my High-dose niacin has the potential to cause complications among people with a liver disorder. Regular intake above the UL could result in flushing, nausea, vomiting, diarrhea, you shouldn't take milk thistle before drinking or during - only after all alcohol has left your system. 5 g doses / 2-3 Make sure you are taking it with a methylated B complex to avoid homocysteine issues and it’s also recommended with liver protective I know very little about supplements, but u deffinitly dont wanna over do this its know to cause liver damage over 20mg a day. Niacin, prescribed for more than 50 years, proves effective in treating cholesterol, but over-the-counter formulas demonstrate no ability to improve cholesterol or prevent heart disease. What I take is mostly just a CNS depressant Gabba AM doesn't appear to cross the BBB (idk how that works though because my dreams are insane when I take it). Thoughts? EDIT 2: The NAC is fine (or at least was not causing damage). I made this mistake. I’ve had a bottle of B3 Niacin (Nicotinic Acid) for over a week, but was scared to try any because of the potential for a bad flush reaction. There is no reason a 20 year long myth should be perpetuated! I have an inkling that sustain release supplements of any kind may be bad for anyone with a liver as compromised as mine currently is. I've read that having milk thistle in your system while you're drinking can actually amplify the damage alcohol does to the liver EDIT: I also remember reading somewhere that theanine is protective of the liver if taken before/while drinking. Please don't take it personally. Histopathologic features that have previously been described in association with niacin‐induced liver injury include necrosis, cholestasis, fibrosis, and/or hepatocyte vacuolization (Table 2). Damage to the vessel is the problem, not sticky stuff. One severely depressed, non-communicative woman who stared out the window every day needed 11,000mg and then she behaved 100% normal. Niacinamide is typically safer in Higher doses of niacin can help lower cholesterol, but long-term treatment with niacin — particul Further resources For more in-depth resources about vitamins, minerals, and supplements, visit our dedicated hub. Don't take it without a proper reason and without consulting a doctor. Hopefully this helps! 30 minutes later; never taking this again. Read your labels carefully, go all the way through the back of the label and make sure your "niacin" isn't niacinamide. medical strength slow release niacin is still on the market, though it may cause liver Weeks 5 and 6, 500mg niacin, 500mg TMG, 500mg resveratrol Weeks 7 and 8, 750mg niacin, 750mg TMG, 500mg resveratrol About me: 39 year old 150lb male, and I'm planning on suggesting the same plan for my mother who is 72 years old ----- My references guiding my plan: Is niacin a worthwhile NAD booster? Extracted products made in Germany during the years between 1998 and 2003 were the culprit of this myth. I have used it in the past, it is a good product. niacin can cause liver damage if you take high doses without also taking a methyl donor. This means that Niacin prevents the production of triglycerides (fat) in the liver. Niacinamide is the dangerous version, it can cause liver damage, do not take niacinamide or any other extended or long release or sustained release version of niacin. Pyridoxine (vitamin B6), for example, in very high doses (greater than 250mg/day for extended periods) can cause nerve damage and numbness. Posted by u/[Deleted Account] - 6 votes and 11 comments Today I noticed a somewhat alarming looking warning in its Daily Analysis: "Niacin UL (DRI Tolerable Intake Level) is 35mg, you have consumed 38mg on Dec 16. 3g niacin is not so high, that’s what I take daily, just for health maintenance. Niacin happens to act on the same receptor as ketone body (beta-hydroxybutyrate) by temporarily BLOCKING lipolysis which will rebound to much higher level after 1h. I try to sleep but my temperature can go up so much I wake up. I just bought this brand 21st Century Tablets Niacin - 100mg. I get liver pain if I go binge drinking for a day or two. Niacin has been indicated to be mildly toxic to the liver so long term and excessive use of energy drinks “could” be a factor in people getting hepatitis (inflammation and damage to the liver) but more research and evidence is needed here. ( I really don't know why; I don't drink or smoke or had Hepatitis infections). Does anyone take niacin to lower bad cholesterol my doc called and said mine is high and they want me to take a stress test im only 25 and my parents Skip to main content Open menu Open navigation Go to Reddit Home Extended release niacin may help you although you need to be more careful about watching your liver enzymes. Although niacin supplementation to increase NAD levels has been found to have a modest remission effect on fatty liver in an animal study 7 and to be associated with improved muscle performance in a human intervention study, 8 no prospective studies have been conducted assessing the association between niacin intake levels from foods and the risk of In the book "Niacin" by Abram Hoffer it says that normal niacin (as nicotinic acid), the flush version, is fine and won't damage the liver. Lower the dose. I take Niacin (Vitamin B3) as part of a daily supplement, and have found that combining a psilocybe cubensis micro dose of 0. Do NOT, I repeat, do NOT take niacin over-time. Very wise of you to take Liver Shield. slow-release, or time-release, or slowly taking it throughout the day puts extreme stress on your liver and can cause serious damage. The equation of longevity by damage to the body is always the same I've not read any studies on it so I can only speak anecdotally but it hasn't been a problem for me. It's difficult to research online because most of what I read says that the liver injuries are linked to extended release niacin but nobody talks about extended release Niacinamide. A lot of people also get relief from fatty liver on keto but keto didn’t relieve any of my illnesses, but carnivore made all the difference. Even if it is from supplements, though, the 35mg Tolerable Upper Limit set by the Institute of Medicine was primarily to avoid the mostly harmless "niacin flush," and much higher doses are required to cause liver damage in most people. I often just take Milk thistle On the other hand, the other form of niacin (no flush) causes liver damage. Andrew Weil, a highly respected doctor also known as the “father of integrative medicine” came out and debunked the kava liver damage association. niacin uses methyl groups in the body, and TMG helps replace those. A time-release form of niacin reduces flushing. Use nmn" "Sinclaire propaganda. Taking it once at a time spikes liver enzymes but doesn't appear to cause long term issues. So don't Most of the liver toxicity is with the long acting/sustained release niacin. Niacin can cause mild-to-moderate serum "Stop taking niacin. However, I am concerned about the possible negative effects of taking so much non-flush Niacin, so I bought the flush kind of Niacin. No liver toxicity with straight niacin Reply reply More replies. Everyone should take flush niacin, never niacinamide (or only very low doses). If nmn works and niacin works, then any lack of liver damage from nmn is simply because it's less active. Expand user menu Open settings The Stammets Stack denotes a minimum dosage of niacin at 100mg (200mg to WebMD, adults should not take no more than 35mg daily. If you take it, take it all at once. You are hurting your liver for Testosterone at 27. Take higher doses of flush niacin like 1-2. This combination has dramatically improved my mental health. linxhivf nrrhq zmsvwk qew eahuays qmhww ewzpdr mwjxw rgu uqvem